Numbat is a haplotype-aware CNV caller from single-cell transcriptomics data. It integrates signals from gene expression, allelic ratio, and population-derived haplotype information to accurately infer allele-specific CNVs in single cells and reconstruct their lineage relationship.
Numbat can be used to:
- Detect allele-specific copy number variations from scRNA-seq
- Differentiate tumor versus normal cells in the tumor microenvironment
- Infer the clonal architecture and evolutionary history of profiled tumors.
Numbat does not require paired DNA or genotype data and operates solely on the donor scRNA-data data (for example, 10x Cell Ranger output). For details of the method, please checkout our paper:
For a complete guide, please see Numbat User Guide.
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